Clinical Practice Guidelines

One of the primary objectives of the ISRS is to elucidate best practices and provide guidance for safe and effective practice of SRS and SBRT. During the past several years, a number of important intra- and extra-cranial guidelines have been published under the direction of, and with input from, global experts who form the committees. 

The guideline development process reflects our commitment to mentoring young professionals in the fields of SRS/SBRT, as each junior guideline lead is partnered with a senior committee member to guide the process and writing of the guideline. The intent is to foster the next generation of leaders in SRS/SBRT. The ISRS is grateful for the considerable time and effort of each of the contributors. Most of the following guidelines may be accessed free of charge via open access by clicking on the publication titles.

Guidelines Committee Members

Intra-cranial committee: Sahgal A (Chair), Gorgulho A, Levivier M, Paddick I, Ma L, Fariselli L, Sheehan J, Suh J, Yomo S (Co-chair), Regis J, Pollock B, Kotecha R (Co-chair)

Extra-cranial committee: A Sahgal (Chair), Lo S, Slotman B, Kim M, Tree A, Guckenberger M, Scorsetti M, Kotecha R (Co-chair), Louie A (Co-chair)

New ISRS Guidelines Published:

STEREOTACTIC BODY RADIOTHERAPY FOR PRIMARY RENAL CELL CARCINOMA: A SYSTEMATIC REVIEW AND PRACTICE GUIDELINE FROM THE INTERNATIONAL STEREOTACTIC RADIOSURGERY (ISRS)
Shankar Siva, Alexander V Louie, Rupesh Kotecha, Melissa N Barber, Muhammad Ali, Zhenwei Zhang, Matthias Guckenberger, Mi-Sook Kim, Marta Scorsetti, Alison C Tree, Ben J Slotman, Arjun Sahgal, Simon S Lo

DOI: 10.1016/S1470-2045(23)00513-2

ISRS Guidelines - Intracranial

Benign Tumors

Constantin Tuleasca, Rupesh Kotecha, Arjun Sahgal, Antonio de Salles, Laura Fariselli, Ian Paddick, Bruce E. Pollock, Jean Régis, Jason Sheehan, John H. Suh, Shoji Yomo & Marc Levivier

Mathieu D, Kotecha R, Sahgal A, De Salles A, Fariselli L, E. Pollock B, Levivier M, Ma L, Paddick I, Regis J, Yomo S, H. Suh J, Rubens M, P. Sheehan J.
J Neurosurg Spine. 2021 Sep 3.

Marchetti M, Sahgal A, A F De Salles A, Levivier M, Ma L, Paddick I, Pollock BE, Regis J, Sheehan J, Suh JH, Yomo S, Fariselli L
Neurosurgery. 2020 May 28.

Kotecha R, Sahgal A, Rubens M, De Salles A, Fariselli L, Pollock BE, Levivier M, Ma L, Paddick I, Regis J, Sheehan J, Yomo S, Suh JH
Neuro Oncol. 2020 Mar 5;22(3):318-332

Lee CC, Trifiletti DM, Sahgal A, DeSalles A, Fariselli L, Hayashi M, Levivier M, Ma L, Álvarez RM, Paddick I, Regis J, Ryu S, Slotman B, Sheehan J. 
Neurosurgery. 2018 Mar 15.

Tsao M, Sahgal A, Xu W, De Salles A, Hayashi M, Levivier M, Ma L, Martinez R, Régis J, Ryu S, Slotman B, Paddick I
Journal of radiosurgery and SBRT. 2017 Vol. 5 (1), 5-24.

Functional/Epilepsy

Tuleasca C, Régis J, Sahgal A, De Salles A, Hayashi M, Ma L, Martínez-Alvarez R, Paddick JI, Ryu S, Slotman BJ, Levivier M.
J Neurosurg. 2018 Apr 27:1-25.

Martínez-Moreno N, Sahgal A, De Salles A, Hayashi M, Levivier M, Ma L, Paddick I, Régis J, Ryu S, Slotman B, Martínez-Álvarez R
Journal of Neurosurgery 2018 23(2) 1-12.

McGonigal A, Sahgal A, De Salles A, Hayashi M, Levivier M, Ma L, Martinez R, Paddick I, Ryu S, Slotman B, Régis J
Epilepsy research 2017 Vol 137 123-131.

Malignant Tumors

Balamurugan Vellayappan, Mary Jane Lim-Fat, Rupesh Kotecha, Antonio De Salles, Laura Fariselli, Marc Levivier, Lijun Ma, Ian Paddick, Bruce E Pollock, Jean Regis, Jason P Sheehan, John H Suh, Shoji Yomo, Arjun Sahgal

Redmond KJ, De Salles A, Fariselli L, Levivier M, Ma L, Paddick I, Pollock BE, Regis J, Sheehan J, Suh J, Yomo S, Sahgal A.
Int J Radiat Oncol Biol Phys. 2021 Sep 1;111(1):68-80. Epub 2021 Apr 20

Chao S, De Salles A, Hayashi M, Levivier M, Ma L, Martinez R, Paddick I, Régis J, Ryu S, Slotman B, Sahgal A
Neurosurgery 2017 11(3)

Grishchuk D, Dimitriadis A, Sahgal A, De Salles A, Fariselli L, Kotecha R, Levivier M, Ma L, Pollock B, Regis J, Sheehan J, Suh J, Yomo S, Paddick I

Vascular Disorders

Singh R, Chen C-J, Didwania P, Kotecha R, Fariselli F, Pollock BE, Levivier M, Paddick I, Yomo S, Suh JH, Sahgal A, Sheehan JP
Neurosurgery. April 2022. Publish Ahead of Print (2)

Graffeo CS, Sahgal A, De Salles A, Fariselli L, Levivier M, Ma L, Paddick I, Regis JM, Sheehan J,Suh J, Yomo S, Pollock BE
Neurosurgery. 2020 Feb 17.

ISRS Guidelines - Extracranial

Kidney

Shankar Siva, Alexander V Louie, Rupesh Kotecha, Melissa N Barber, Muhammad Ali, Zhenwei Zhang, Matthias Guckenberger, Mi-Sook Kim, Marta Scorsetti, Alison C Tree, Ben J Slotman, Arjun Sahgal, Simon S Lo

Liver

Sun Hyun Bae , Seok-Joo Chun , Joo-Hyun Chung , Eunji Kim , Jin-Kyu Kang , Won Il Jang , Ji Eun Moon , Isaure Roquette , Xavier Mirabel , Tomoki Kimura , Masayuki Ueno , Ting-Shi Su , Alison C Tree , Matthias Guckenberger , Simon S Lo , Marta Scorsetti , Ben J Slotman , Rupesh Kotecha , Arjun Sahgal , Alexander V Louie , Mi-Sook Kim

Lung

Spine

Myrehaug S, Sahgal A, Hayashi M, Levivier M, Ma L, Martinez R, Paddick I, Régis J, Ryu S, Slotman B, De Salles A J Neurosurg Spine. 2017 Jul 14:1-8.

Husain ZA, Sahgal A, De Salles A, Funaro M, Glover J, Hayashi M, Hiraoka M, Levivier M, Ma L, Martínez-Alvarez R, Paddick I, Régis J, Slotman BJ, Ryu S
J Neurosurg Spine. 2017 Jun 9:1-8.

Faruqi S, Chen H, Fariselli L, Levivier M, Ma L, Paddick I, Pollock BE, Regis J, Sheehan J, Suh J, Yomo S, Sahgal A Pract Radiat Oncol. 2021 Oct 19:S1879-8500(21)00282-4.

ISRS Guidelines - Intracranial - In Development

  • Steve Braunstein, Lijun Ma. Multiple Brain Metastases (>5)
  • Christopher S. Graffeo, Bruce Pollock. High-grade SM AVM
  • Anne Balossier, Jean Regis. KOOS 1-2 Acoustic
  • Shreya Saxena, Manmeet Ahluwalia. EGFR-m NSCLC brain mets
  • Valentina Pinzi, Laura Fariselli. Recurrent GBM

ISRS Guidelines - Extracranial - In Development

  • Timothy Nguyen, Allison Tree. Non-spine bone metastases
  • Ciro Franzese, Maria Scorsetti. Liver Metastasis
  • Erin Murphy, Rupesh Kotecha. Pediatric SBRT
  • Irene Karam, Arjun Sahgal. Head and Neck SBRT