ISRS 35 year anniversary logo
ISRS 35 year anniversary logo

Treatment Type: SBRT

#45440: Deliverability of Online Adaptive Prostate SBRT Plans

Purpose:Phantom-based pre-treatment verification is not possible for online adaptive plans, because of the patient is lying on the treatment table during this type of radiation therapy. Currently, patient-specific QA (PSQA) relies on a secondary independent dose calculation of the treatment plan. We aim to analyze the dosimetric accuracy of the type of online adaptive SBRT […]

#45484: Non-myelitis neurologic toxicity of stereotactic ablative radiotherapy for spine

Purpose: Radiation myelitis (RM) is the most dreaded complication of stereotactic ablative radiotherapy (SABR) for the spine. We investigated radiation-induced radiculo-plexopathy (RIRP) in patients who underwent SABR for spinal metastases. Materials and Methods: Patients who received SABR for metastatic spine tumors arising in C3 to T1 and T12 to S2 vertebrae from 2013 to 2023 […]

#45156: Impact of simultaneous integrated dose boost in spinal bone oligometastases stereotactic body radiotherapy

IntroductionRadiotherapy has a known role in the treatment of symptomatic spinal bone metastases, but its use with ablative purpose remains controversial. The aim of our study is to evaluate efficacy and toxicity of stereotactic body radiotherapy (SBRT) in treating spinal oligometastases.  MethodsA series of spinal oligometastatic patients was treated between 2018 and 2023. The clinical […]

#44910: Prognostic Factors for Local Failure and Overall Survival in Patients with Epidural Disease at the Cauda Equina: A Clinical, Anatomic and Dosimetric Analysis N°P037

Background and purpose: Paraspinal involvement has been consistently reported as a predictor of local failure post-stereotactic body radiotherapy (SBRT) for spinal metastases. We aim to investigate the characteristics of paraspinal disease and their impact on outcomes. Materials and methods: Patients who underwent SBRT for spinal metastases with paraspinal involvement, identified from a single-institutional prospective database, […]

#40100: A machine learning tool for prediction of vertebral compression fracture following stereotactic body radiation therapy for spinal metastases

Purpose: Spine stereotactic body radiotherapy (SBRT) achieves impressive rates of overall pain response and local control. Rates of adverse effects following spine SBRT are low with the most common complication being vertebral compression fracture (VCF), at an estimated rate of 9% in a recent meta-analysis. Several clinical, radiographic and dosimetric factors predictive of VCF have […]

#39686: Stereotactic body radiotherapy (SBRT) for sacral metastases, the impact of following recommended target volume delineation on risk of local failure

Purpose: Spine stereotactic body radiotherapy (SBRT) is considered a standard of care in the mobile spine, however, mature evidence reporting outcomes specific to sacral metastases is lacking. Furthermore, there is a need to validate the existing sacral SBRT international consensus contouring guidelines to define the optimal contouring approach. We report mature rates of local failure (LF), […]

#39773: Outcomes following stereotactic body radiotherapy for spine metastases with paraspinal disease extension – does volume matter?

Purpose: Paraspinal involvement is associated with worse local control following stereotactic body radiotherapy (SBRT) for spinal metastases. The aim of this study is to investigate the characteristics of paraspinal disease and determine their impact on outcomes. Methods and materials: We retrospectively reviewed patients who had SBRT for spinal metastases with paraspinal involvement, identified from a […]

#40087: Single-fraction MR-guided stereotactic ablative radiation therapy for extracranial tumors, the miami cancer institute experience

Background: Ablative radiation therapy can be selectively delivered to extracranial tumors, usually over several days but rarely in a single fraction due primarily to concerns regarding normal tissue toxicities, mitigation of which requires tight PTV margins, an option historically limited by the low soft tissue resolution and lack of continuous intrafraction visualization/tracking as well as beam-gating […]

#39844: Stereotactic radiotherapy for colorectal cancer metastases – review of clinical outcomes

Background/Methods: Despite advances in systemic therapy, survival in metastatic colorectal cancer (mCRC) remains poor with fewer than 20% being alive at 5 years from diagnosis (1). The utility of stereotactic body radiotherapy (SBRT) and stereotactic radiosurgery (SRS) allowing dose escalation to achieve improved local control has risen in the treatment of mCRC. Despite the growing […]

#40182: SAbR in synchronous and metachronous oligo-metastatic non-small cell lung cancer, START NEW ERA-OM non randomised phase II trial

Purpose: Thanks to diagnostic and pharmacological advances there is growing interest in the treatment of oligo-metastatic (oligo-M) non-small cell lung cancer (NSCLC).  This is a phase II trial (Clinical Trial NCT06207292) to assess efficacy and safety of stereotactic ablative radiotherapy (SAbR) in oligo-M NSCLC patients. Material and Methods: Synchronous and metachronous (oligo-recurrent, oligo-persistent and oligo-progressive) […]

#39576: Tolerability and outcomes of neuroendocrine tumors treated with peptide receptor radionuclide therapy and stereotactic body radiation therapy

Introduction: Peptide receptor radionuclide therapy (PRRT) and stereotactic body radiation therapy (SBRT) for neuroendocrine tumors (NET) may have a synergistic impact, as PRRT may treat widely metastatic disease and SBRT may target areas of tumor heterogeneity. There is a paucity of data evaluating the potential safety and efficacy of this treatment strategy; this is the […]

#40103: Stereotactic ablative radiation therapy (SABR) for lung metastases from sarcoma primaries, a systematic review and meta-analysis of safety and efficacy

Purpose: Though promising single institution retrospective and prospective studies have been reported on stereotactic ablative radiation therapy (SABR) for management of lung metastases from sarcoma primaries as an alternative to the historical standard of metastasectomy, larger multi-institutional series are limited that report on both safety and efficacy with this treatment paradigm. Thus, we conducted a […]

#40150: Stereotactic ablative radiotherapy for the liver, employing breath-hold techniques and utilizing intrafraction diaphragm registration

Background: There have been significant changes in the role of radiotherapy for liver cancer. In stereotactic body radiotherapy (SBRT) for liver cancer, effective management of respiratory motion poses a major challenge. At our hospital, we have implemented the flattening filter-free volumetric modulated arc therapy (FFF-VMAT) for liver cancer treatment. However, a key limitation is the […]

#39792: Pancreas SBRT in total endotracheal anesthesia, a feasibility analysis

It has been demonstrated that BED10 > 100 significantly improves local control and overall survival in patients with locally advanced pancreatic cancer (LAPC).  However, performing SBRT for targets with a pancreas localization can be challenging due to motion of the target (respiratory and peristaltic) and proximity to organs at risk. To deal with OAR proximity and […]

#40145: SBRT after neoadjuvant chemotherapy for locally advanced pancreatic cancer, preliminary institutional results

Background: NAC for tumor downstaging, better local/distal disease control, and higher R0 resection rate, followed by pancreatectomy are the two pillars of the management of LAPC. The potential additional role of  radiotherapy remains controversial.   Materials and Methods: In our tertiary referral center, patients with LAPC undergo a complete course of NAC (mostly FOLFIRINOX), cross-sectional […]

#40190: Uncovering the armpit of SBRT, an institutional experience with stereotactic radiation of axillary metastases

Purpose/Objective(s): The growing use of stereotactic body radiotherapy (SBRT) in metastatic cancer has led to its use in varying anatomic locations. The objective of this study was to review our institutional SBRT experience for axillary metastases (AM), focusing on outcomes and process. Materials/Methods: Patients treated with SBRT to AM from 2014-2022 were reviewed. Cumulative incidence functions were used […]